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102 , S1S127 (2022)
Amid overwhelming demand, the company recently said it would throttle starter doses of the drug in the U.S
Meta-analyses of these and other studies have demonstrated: Reductions in total cholesterol typically in the range of 15% from baseline, varying by agent and population Decreases in LDL cholesterol ranging from 17%, generally more modest than dedicated lipid-lowering therapies Reductions in triglycerides of 515%, with greater effects often seen in those with higher baseline levels Variable effects on HDL cholesterol , with small increases (1-2%) or neutral effects reported The magnitude of lipid improvements appears to correlate with the degree of weight loss achieved, suggesting that metabolic benefits may be partially mediated through adiposity reduction
Analyses were based on on-treatment data at the primary endpoint from patients adherent to treatment (taking 75% study drug)
In conclusion, the analysis offers cautious, low-certainty reassurance that inadvertent early exposure to GLP-1 receptor agonists during pregnancy is not strongly linked to major birth defects or other severe outcomes
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